Kurome: Akame's little sister. Both she and Kurome were sold to the Empire by their parents when they were little and were trained to be assassins. However, her sister was not in the top 7 assassins, presumably due to the bond as siblings. Kurome is both the person she loves the most and the person whom she wishes to kill the most ever since Kurome decided to stay with the Empire when Akame defected to Night Raid. Although as children, both were much closer and were seen doing many things together, as their separation greatly affected them, not wanting to be separated. Their initial standing is hostile and remains so for a bulk of the series, however as time goes on, Wave becomes more of a positive influence on her and eventually changes her stand to wanting to stop Akame, while still believing Night Raid are a malevolent group. Once Wave saves Kurome, the siblings are at last able to bond again, saying that they would love to be proper sisters to each other again, shortly before parting ways.
Wave: Akame regarded Wave simply as an initially, albeit a highly threatening one, landing the first clear and hard hit on her in their first battle against each other, with two allies beside her. When they face off against each other, she decides he could be appealed to and stops the fight to talk to him about his stance with the Empire and Kurome, feeling he is a good person deep down. Wave in return starts thinking that she's an awful sister for running for the option of killing Kurome in attempt to save her, but doesn't fight her, wanting the sisters to be together again. Once Wave shatters Akame's illusion that Kurome could not be saved and eventually does so himself, the two start to have a more respectful relationship.
Tatsumi: Akame is initially indifferent to Tatsumi, refusing to share meat with him until he officially joins Night Raid. Though she often hides her emotion, she worries about him while he is away on missions. Tatsumi vows to never put her through the pain of losing him. Akame herself states to Tatsumi, that just like everyone in Night Raid, he is a valuable friend and that she will always be there to save him in his time of need. Tatsumi is one of the main members of Night Raid that Akame is closest to.
Leone: Akame and Leone appear to be good friends (Leone even considers Akame to be her best friend), but their relationship is sometimes used for comical effect, as seen when Leone punches her when she comments on the difference in their weight. Leone tells Akame that she is her best friend shortly before parting ways, whereas she dies afterwards.
Najenda: Akame is trusted by the boss enough to be left in charge of Night Raid during her absence. Although they aren't shown socializing often, it is known that Najenda herself persuaded Akame to defect from the Empire and join the Revolutionaries, and Night Raid.
Tsukushi: Akame and Tsukushi are best friends during their time in the Elite Seven. Tsukushi tried to comfort Akame when she was distraught over Martha's and later Cornelia's death. They also occasionally sleep together.
Green: Akame is aware that Green is in love with her, but doesn't return his feelings. She does value him as a friend and comrade.
Cornelia: Akame appreciated Cornelia's caring personality and called her "Corey". Akame was very distraught about Cornelia's death and even cried openly.
Najasho: Akame respected Najasho's abilities and leadership. She appreciated that he tried to cheer her up after Martha's death.
Poney: Akame and Poney don't interact often, but they seem to get along well and briefly teamed up while teasing Tsukushi in a hot spring.
Gozuki: Akame seemed to respect him and even called him father. However, Gozuki noted that she doesn't adore him like the other female members of the Elite Seven.
Merraid Oarburgh: Akame was captured by Merraid and began to see the true corruption of the empire. Merraid tried to get Akame to switch factions by means of seduction. Merraid stole Akame's first kiss, and many kisses after, which Akame felt the pleasure after but fought it off. It was strongly hinted that Akame was sexually molested by the Oarburgh's, and Akame had a near sexual encounter with Merraid, before trying to kill her.
Hinata: Akame was indebted to Hinata after she rescued Akame from the beach she washed ashore after her ship was destroyed. As a token of gratitude, Akame taught her swordsmanship. When Hinata was promoted to Captain, Akame joined her unit as an assassin, and she allowed her to do as she pleased according to her specialty.
Strange Elder: Akame respects Strange Elder for allowing her to join his class under Hinata's recommendation. She was indebted to him when he procures the medicine to ease down Murasame's curse for a short amount of time. In exchange, she attends the class and giving the combat skill practice especially to Hinata
Yomihime: Akame manages to intercept Yomihime from slaying Hinata in time during the battle of Mt. Kageboshi. The duel ends in Akame's victory by forcing her to retreat. Yomihime vow vengeance for this and later, both are reunited again at Shiranui Fortress to resume the duel once again.